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Cysteine proteases regulate many important physiological processes, and are potential targets for the treatment of many diseases.
Key Benefits
The currently available cysteine protease inhibitors tend to be reactive compounds that irreversibly modify other proteins in addition to their targets, and therefore exhibit nonspecific toxicity. There are few specific inhibitors of DUBs. The compounds reported here display good potency and selective toxicity in cell-based assays
Applications
Cysteine proteases regulate many important physiological processes, and are potential targets for the treatment of many diseases, including inflammation, arthritis, osteoporosis, gingivitis, cancer, neurodegeneration and infection. These compounds are related to naturally occurring compounds that have anti-cancer activity.