Mouse Monoclonal Antibodies

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Monoclonal Antibodies Available for Non-Exclusive Licensing: Anti-NFPR, Anti-gp91phox, Anti-p22phox and Anti- CAP-18 are detailed below. Anti-N-formyl peptide receptor antibodies against human neutrophil N-formyl peptide receptor, NFPRa and NFPRb: NFPRa and NFPRb can be employed in the study of inflammation sites where the accumulation, activation and control of neutrophils is partly driven by the binding of N-formyl peptides to N-formyl peptide chemoattractant receptors (FPRs). NFPRa Anti-FPR1 (human neutrophil N-formyl peptide receptor 1) and anti-FPR2 (human neutrophil N-formyl peptide receptor 2); IgG1; used as hybridoma culture supernatant and purified protein; epitope mapped, recognizing cytoplasmic cterminal tail region containing residues of FPR1 (305-GQDFRERLI-313) and of FPR2 (306- GQDFRERLI-314); Walid S. Maaty, et al J. Biol. Chem. 2013, 288:27042-27058. NFPRb Anti-FPR1 (human neutrophil N-formyl peptide receptor 1); IgG1; used as hybridoma culture supernatant and purified protein; epitope mapped, recognizing a region of FPR1 containing the cytoplasmic c-terminal tail residues 338- STLPSAEVELQAK-350; sensitive to C-terminal tail phosphorylation; Walid S. Maaty, et al J. Biol. Chem. 2013, 288:27042-27058. Anti-gp91phox (human neutrophil flavocytochrome b large subunit; aka beta subunit, Nox2, cytochrome b559 or cytochrome b558) mAb 54.1 IgG1, used as hybridoma culture supernatant and purified protein; epitope mapped, cytoplasmic domain (ref.: Burritt et al J Biol Chem. 1995 270:16974-80). cross reacts with Nox1, Nox3, Nox4, GRP58 (ref.: Baniulis et al. BBA 2005 1752:186-96). mAb NL7 IgG1, used as hybridoma culture supernatant and purified protein; epitope mapped, cytoplasmic domain. (ref.: Burritt et al J Immunol. 2003 170:6082-9). mAb CL5 IgG1, used as hybridoma culture supernatant and purified protein; epitope mapped, extracellular domain. (ref.: Baniulis et al Eur J Haematol. 2005 74:337-47). Anti-p22phox (human neutrophil flavocytochrome b small subunit; aka alpha subunit, cytochrome b559 or cytochrome b558) mAb 44.1 IgG2, used as hybridoma supernatant only; does not survive low pH treatment w/o special care; epitope mapped, cytoplasmic domain (ref.: Burritt et al J Biol Chem. 1995 270:16974-80). mAb CS9 IgG1, used as hybridoma culture supernatant and purified protein; epitope mapped, cytoplasmic domain (ref.: Taylor et al J Immunol. 2004 173:7349-57). Anti-human neutrophil CAP-18 H7 IgG1, used as hybridoma supernatant and purified protein; epitope mapped, holoprotein (ref.: Stie et al J Leukoc Biol. 2007 82:161-72).