Cancer detection

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Background Confocal Raman spectroscopy alone can isolate signatures from different layers of tissue but yields little information about tissue microstructure. Confocal imaging alone provides structural information of the tissue. Gross spatial imaging is important to register the microscope image with the lesion. Technology Raman spectroscopy is a powerful technique for probing the biochemistry of the tissue and can be used to provide accurate differential diagnosis of early disease.  However, Raman spectroscopy by itself yields little information about the tissue microstructure and the signals from it are too weak for imaging. By combining Raman spectroscopy with confocal imaging, this device yields information about tissue structure and biochemistry, allowing for a complete diagnosis. A CCD camera in the probe captures large white-light images of the lesion, enabling registration between the microscope image and features of the lesion that are superficially visible. Potential applications for this instrument include non-invasive scanning for skin cancer and a variety of other organ systems.