Healthcare & Pharmaceuticals
Wnt Trafficking in Gastrointestinal Cancer
Recent evidence from the Scholpp lab suggested that Wnt/beta-catenin ligands are loaded on and distributed by signalling filopodia in vertebrate tissue (Stanganello et al., 2015). The generation and dynamic of this transport mechanism is regulated by components of the Wnt/PCP signalling pathway. Controlling Wnt trafficking will allow us to regulate Wnt signalling dependent cancers such as gastrointestinal cancers.