University of California, Los Angeles

For nearly 100 years, UCLA has been a pioneer, persevering through impossibility, turning the futile into the attainable.

Innovations

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                                    Published
                            
                Medical
            
Neuronal Survival Post-Injury
                Drug can be applied to the injury site of the spinal cord, and improves neuronal survival by inhibiting the post-injury aggregation of α-synuclein.
            
By
                            University of California, Los Angeles
                        
Reference Number  
                04771
            
Last Update  
                 Nov 15, 2021
            
                                    Published
                            
                Medical
            
Drugs for Protein Misfolding
                Drug applicable to a broad range of protein misfolding diseases like Alzheimer's and Parkinson's Diseases. Prevents formation of new aggregates and breaks pre-formed aggregates
            
By
                            University of California, Los Angeles
                        
Reference Number  
                04770
            
Last Update  
                 Nov 15, 2021
            
                                    Published
                            
                Medical
            
Proteopathic Seed Transmission
                Specific molecular pathway can be inhibited by small molecules to stop proteopathic tau seed transmission. Therapeutic strategy is applicable across multiple proteopathic diseases.
            
By
                            University of California, Los Angeles
                        
Reference Number  
                04769
            
Last Update  
                 Nov 15, 2021
            
                                    Published
                            
                Medical
            
3D-ExoQuant: Exosome Analysis
                Early and non-invasive detection of surface biomarkers present on exosomes and extracellular vesicles. Allows non-invasive detection of AD biomarkers from brain-derived exosomes.
            
By
                            University of California, Los Angeles
                        
Reference Number  
                04768
            
Last Update  
                 Nov 15, 2021
            
                                    Published
                            
                Medical
            
Molecular Tweezers
                The molecule inhibits the principal cause, not symptom, of AD by disaggregating pre-existing Aβ40 and Aβ42 protein fibrils. The tweezer is non-toxic at concentrations up to 200 μM.
            
By
                            University of California, Los Angeles
                        
Reference Number  
                04767
            
Last Update  
                 Nov 15, 2021