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Rutgers scientists have developed a copolymer formulation to stably release salicylic acid (SA).
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Summary: Rutgers scientists have developed a copolymer formulation to stably release salicylic acid (SA). It holds the promise for promoting topical and surgical wound healing, as SA is known to reduce local pain and inflammation as well as potentially prevent fibrous adhesion formation by reducing scar tissue. The release is stable over a period of around 10 days, which is the critical window for fibrous adhesion formation. The novel formulation is achieved by copolymerization of salicylic acid-based poly(anhydride-esters) (SAPAE) with poly(ethylene glycol) (PEG). The copolymer with SAPAE and PEG has a low glass transition temperature (