Value Added Isotope Synthesis

About

Value Added Isotope Synthesis We have developed an exceptionally mild technique for incorporating single or multiple stable isotopes into compounds with absolute confidence that the isotope(s) are exactly where they were designed to be. Single or multiple isotope combinations based on deuterium, carbon-13, oxygen-18 and nitrogen-15 can be readily incorporated. Features •                Simple and low cost compared to existing multi-label incorporation methods •                Single or multiple identical or different isotopes can be installed •                > 95% incorporation for single and multiple isotopes •                No substitutions or misplacing •                No detectable evidence of isotope scrambling •                Water and nitrogen only by products •                Straightforward protocol. •                Multi-component one-pot reaction.   High fidelity isotope incorporation can be achieved  using this green, metal-free synthesis protocol; a series of isotope labelled and optically active ‘high-value’ building blocks can be readily synthesised with excellent levels of isotope incorporation (>95%) and optical activity (>90%) so no re-submission is required. Developing mild and efficient stable isotope incorporating protocols that generate mission critical molecules is very important to a diverse array of industries, these include: pharmaceutical, biotechnology, analytical, security, environmental, agrochemical as well as high and emerging technology based sectors. The isotope labelled building blocks have been transformed into diverse motifs with a wide variety of structure and function demonstrating the versatility of these ‘lynch-pin’ molecules. These include aza and amino sugars, alkaloid analogues, optically active vicinal amines, amino alcohols, -, -amino acids, medium-ring amides, bicyclic and -lactones, bicyclic amino ethers, spiro heterocycles, oxazolidin-2-ones, chiral non-racemic auxiliaries, imidazolidines, -lactams, pyrrolidines, 5H-pyrrolo[1,2-c]imidazoles, quinoxalines, oxazoles, indolin-2-ones and many others.