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The newly developed device here presented appears to be a promising tool to improve a major constraint in tissue engineering.
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Summary: The construction of a successful tissue engineered tubular graft (TETG) through a porous polymer scaffold requires a high-density cell seeding process with uniform radial distribution. Seeding tubular polymers with standard techniques such as static or dynamic culture is not always feasible due to the variable structures of the polymers. And, if feasible, it usually takes a long culture time (several weeks) to achieve full-thickness cellular content. One of the features that a TETG must have is off-the-shelf availability for patients requiring acute treatment. This seeding technique allows the construct to be seeded in minutes with the desired amount of cells needing only the culture time that each cell type requires to adapt to the scaffold. The newly developed device here presented appears to be a promising tool to improve a major constraint in tissue engineering which is even and bulk seeding of tubular constructs in a short period of time.