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Dysregulation of miRNAs has been shown to contribute to various diseases including cancer, cardiovascular disease, neurodegenerative disease, and diabetes.
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Background: Mature micro RNAs (miRNAs) are 21-22 nucleotide RNAs that are processed from longer transcripts encoded by miRNA genes. miRNA genes are non-protein encoding genes that can be found individually, within intron regions of protein coding genes or in poly-cistronic transcripts. Like siRNAs, miRNAs use base complementarity to silence mRNAs and affect protein expression. miRNAs are important for regulating gene expression during organism development and adult function. Dysregulation of miRNAs has been shown to contribute to various diseases including cancer, cardiovascular disease, neurodegenerative disease, and diabetes. Research has shown that in many instances, miRNA expression can be used as a biomarker for disease. The up- or down-regulation of one or more miRNA can be indicative of disease or a specific disease phenotype. Importantly, since miRNA expression affects disease states miRNA screens have inherent potential to identify therapeutic opportunities using miRNAs from the same screen Applications Potential Anti-Cancer Therapies; to Diagnose and Treat Triple-Negative Breast Cancer; Induction-directed Drug Discovery for Cancer Treatment.