Theraputic Proteins

About

Technology Designing protein therapeutics is becoming one of the fastest growing strategies to treat a variety of diseases including cancer and diabetes. Clustered regularly interspaced short palindromic repeat (CRISPR)/Cas9, a bacterially constructed protein-nucleic acid complex has shown great potential to reverse various genetic disorders. The delivery of this complex into the cell and finally the nucleus is challenging, however, due to the large size of the Cas9 protein. This invention provides a general and efficient protein delivery platform that enables the intracellular delivery of therapeutic proteins. The delivery system involves the use of novel synthetic polymers capable of forming nanocapsules spontaneously under controlled conditions.