siRNA

About

Technology This invention provides a new siRNA delivery vehicle that enables efficient cytosolic delivery of siRNA as well as other nucleic acids. The delivery system involves the use of surface functionalized nanoparticles to form self-assembled superstructures with the protein to be delivered. The nanoparticle-protein assemblies effectively escape endosomal entrapment and rapidly deliver the protein into the cell cytosol or the targeting organelle. This protein delivery system has been successfully demonstrated for the efficient delivery of the CRISPR/Cas9 gene editing system as well as a number of other proteins with different physiochemical properties. Opportunities •       Novel delivery vehicle for the development and delivery of RNAi-based therapeutics •       Advanced tool for life science, drug discovery or biomedical research •       Efficient intracellular nucleic acid delivery system