Purification for DI-MS

About

About this innovation A method for easy and automated (bio)sample preparation for DI-MS.  The aim of Direct-Infusion Mass Spectrometry (DI-MS) is to provide compositional information as well as identification and quantification of specific analytes. Especially nanoelectrospray (nanoESI) is very powerful, but nonoESI emitters are susceptible to clogging due to e.g. protein precipitation and salt crystallization. The new preparation method developed, is based on electroextraction and can be used to selectively extract cations or anions from a sample before infusion into the Mass Spectrometer. This way , for example, proteins and salts can be discarded and therefore the quantitative power of DI-MS can be significantly improved. The method also has the potential to pre-concentrate analytes before infusion into the MS. This entire method has the additional advantage of being easily  integrateble with current (robotic) liquid handling/nanoESI systems. We are looking for partners to bring this technology to the market.  Key benefits Selective extraction of analytes from a sample. Potential of concentrating analytes before infusion into the MS . Improved quantitative power of DI-MS. Easy integration with commercially available nanoESI robots. Proteins and salts can be discarded prior to sample analysis. Application DI-MS Sample pre-treatment in bioanalysis nanoESI