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This technology is low cost and effective production method and it maintains protein structure and enzymatic activity
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Summary Julie Champion, Lina Herrera Estrada, and Zachary Wells from the School of Chemical and Biomolecular Engineering at Georgia Tech have developed a new drug delivery system by creating delivery nanoparticles out of the therapeutic protein to be delivered. The particles are made by conjugating recombinant proteins using disulfide bonds. Having the therapeutic protein be its own delivery method maximizes the amount of protein in the nanoparticle and preserves bioactivity. It also protects the protein by reducing the amount of exposed surface area. The nanoparticles are made by desolvation, and subsequently crosslinking the proteins together to stabilize the particles. Researchers have shown the anti-inflammatory effects of fabricated particles from Salmonella protein AvrA in vitro and in vivo, showed protective effects from an engineered influenza vaccine in mice, and witnessed high levels of cell death in vitro using a Yersinia protein for breast cancer applications using this delivery system.