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POP2 should have greater efficacy and fewer side effects as it is a naturally occurring NF-kB specific inhibitor.
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DESCRIPTION: Researchers at the University of South Florida have discovered a novel human gene, termed POP2 (Pyrin-Only Protein-2), has been shown to be a strong inhibitor of the Nuclear Factor kB (NFkB) protein. NF-kB is involved in a large number of diseases including: Rheumatoid Arthritis Leukaemia/Cancer AIDS Dementia Complex Diabetes Hodgkin’s Disease The causes and symptoms of these and many other diseases are driven by inflammation and immune responses, in which NF-kB plays a strong regulating role. NF-kB also influences cell proliferation, apoptosis (programmed cell death), and the production of cytokines (immune response proteins). NF-kB is the most influential genetic regulator in AIDS, rheumatoid arthritis, and hematogenic cancer cell metastasis. Many of these diseases are currently being treated by modulating the activity of the NF-kB protein using synthetic drugs. POP2 should have greater efficacy and fewer side effects as it is a naturally occurring NF-kB specific inhibitor. POP2’s ability to inhibit NF-kB extends to preventing even the most influential known stimulator, Tumour Necrosis Factor (TNF), from activating NF-kB. ADVANTAGES: Allows modulation of NF-kB activity Alternative to NSAIDs and corticosteroids POP2 is a naturally occurring human protein with the ability to modulate NF-kB’s activity Human Gene Product Can Help Treat Inflammation and Immunity Related Diseases