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A novel formulation that can be use to study the bone remodeling process via bone-like coating on polymer surfaces
About
Background As we are all living longer bone related diseases and disorders are becoming more prevalent and therefore the development of new treatments and drugs is becoming more pertinent. To develop new drugs, it is important to have accurate tissues models for in vitro testing for lead identification and toxicology screening. Common diseases and disorders which affect bones include, osteoporosis, Paget’s disease, osteonecrosis, bone tumours, osteoarthritis, and osteopenia. Technology Overview Scientists at Newcastle University have developed a novel formulation which can create a bone-like coating on polymer surfaces which can be used to study the bone remodeling process.
Key Benefits
Can be used to coat a variety of different cell culture plates Once coated plates can be stored at room temperature Allows the setup of osteoblast-osteoclast co-culture models in a biomimetic environment. Able to observe and measure both osteoblast and osteoclast activity in one experiment – reducing time and cost when compared to other osteo models (Figure 1). Can be fluorescently labelled – suitable for high-throughput screening can visualize mineral deposits of cells and coating (Figure 2) Allows successful osteogenic differentiation of bone marrow derived human mesenchymal stem cells in biomimetic environment, which fails on conventional calcium phosphate coated cell culture dishes.