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Integrated syringe combines blood sample collection and nucleic acid preparation functions to speed diagnostic testing for infectious diseases.
About
This novel syringe simultaneously draws and prepares blood samples for nucleic acid detection. Hence, a simple blood draw results in a prepared sample ready for nucleic acid detection. The syringe contains a cylindrical cam mechanism in the plunger to perform blood tasks that are typically done at a lab (blood lysis, DNA/RNA capture, washing and elution). As blood is drawn from a patient, the vacuum created by the plunger actuates valving that automatically switches between the various preparation tasks. The prepared nucleic acid sample can be analyzed by polymerase chain reaction (PCR).
Key Benefits
Low cost and mass-reproducible Automates labor-intensive sample preparation (collects and processes samples directly from patients) Requires no power or external supplies Can be adapted to detect various infectious diseases
Applications
Point-of-care testing Laboratory/research use