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Compared to original gA, these gA mutants are highly potent against bacteria but more water-soluble, less-toxic to mammalian cells.
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Summary The inventors have synthesized several gramicidin A mutants with only 15 amino-acid residues as novel antimicrobial peptides (AMPs) to eradicate bacteria with multiple-drug resistant. Invention Scientists in Boston College have synthesized several mutant forms of gramicidin A (gA), a fifteenresidue amino-acid peptide originally from Bacilllus brevis, to eliminate bacteria with novel regiment. Like other antimicrobial peptides (AMPs), these gA mutants can destroy bacterial pathogens by disrupting their cellular membrane, a unique anti-bacteria mechanism that is difficult for bacteria to acquire resistance. Compared to original gA which has been used as active ingredient in some antibiotic ointment, these gA mutants are highly potent against bacteria but more water-soluble, less-toxic to mammalian cells. These advantages position them as promising systemic antibiotics.