Nanoparticles

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Poly(Sialic Acid)-Based Nanoparticles for Drug Delivery This invention provides poly(sialic acid)-based nanoparticles to be used as a carrier for drug delivery in the treatment of systemic diseases. Poly(sialic acid) is a biodegradable polysaccharide for which the body has no known receptors. This minimizes reuptake of the associated therapeutic drug and thereby allows for extended circulatory stability while maintaining sustained therapeutic release. Technology Overview Nanoparticle carrier systems for drug delivery are important for the treatment of systemic diseases such as rheumatoid arthritis, and neuronal disorders, such as spinal cord injury. These drug delivery systems strive to employ a material for which the body possesses no known receptors in order to prevent premature clearance of the drug delivery system. Poly(sialic acid) is a non-immunogenic, biodegradable polysaccharide for which the body possess no known receptors. Consequently, the use of poly(sialic acid) in a carrier system minimizes uptake of the associated therapeutic agents by the reticuloendothelial system. In treatment of neurological disorders, poly(sialic acid) has increased plasticity of glial scar tissue, thereby enhancing axonal regeneration. By incorporating poly(sialic acid) into nanoparticles for controlled delivery of therapeutics, such as growth factors, the drugs can act in conjunction with the carrier system to promote regeneration. Advantages Associated therapeutics remain in circulatory system longer than conventional materials while still permitting sustained therapeutic release Promotes axonal regeneration and helps minimize or reverse neurological disorders Limitations no limitations available. Other Information Inventor: Rebecca Bader, http://lcs.syr.edu/facultyandstaff/faculty.aspx?id=2116. Suggested Uses no suggested uses available Development Stage Academic Research Technology Sectors Biotechnology Health and Safety Nanotechnology Imaging Biomedical Drug Delivery Medical Tags no applicable tags specified File Number 100667 IP Protection no associated ip specified Publications no available publications specified