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The technology offers a simpler version for preparing bis(LA) and provides high reaction efficiency at each reaction step. It is fully compatible with a mild photoligation strategy
About
Tech ID: 16-065 Patents: Pending Description: We have developed a versatile strategy to prepare a series of multi-coordinating and multifunctional ligands optimized for the surface-functionalization of luminescent quantum dots (DGs) and gold nanoparticles (AuNPs) alike. Our two new sets of multi-dentate ligands can promote the dispersion of both QDs and gold nanoparticles in buffer media with colloidal stability over a broad range of conditions, while conferring compactness and biocompatibility. The present synthetic scheme starts from L-aspartic acid to develop a versatile platform that allows the controllable coupling of one or more LA groups, one or more polyethylene glycol (PEG) moieties, along with terminal reactive groups, yielding a series of molecular-scale ligands with various architectures and selective reactivity. By attaching various combinations of lipoic acid and PEG chains on the aspartic acid, via peptide coupling chemistry, we have prepared a series of reactive ligands presenting either one PEG chain appended with multiple lipoic acid, or multiple PEG chains attached onto one lipoic acid. Advantages: Offers a simpler version for preparing bis (LA)-appended ligands compared to the Michael addition reaction we have previously employed Provides high reaction efficiency at each reaction step, the ligand synthesis can be easily scaled up and various functional groups can be attached easily Ligands are fully compatible with a mild photoligation strategy to promote the in-situ ligand exchange and phase transfer of hydrophobic QDs to buffer media