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Monoclonal antibody to CD6. CD6 is a surface molecule expressed on T cells and some B cells. It may also play a role in diseases such as multiple sclerosis and rheumatoid arthritis
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Background: Researchers at Stanford have created a monoclonal antibody to CD6. CD6 is a surface molecule expressed on T cells and some B cells. It may also play a role in diseases such as multiple sclerosis and rheumatoid arthritis. The precise function of CD6 in regulating T cell responses and in disease pathogenesis is still unclear. CD6 may also be used to identify regulatory T cells (Tregs) based on their low/negative CD6 expression. To further study the role of CD6, the inventors have developed this rat anti-mouse CD6 monoclonal antibody, IgG2b isotype. It can be used as a research tool to study CD6. Stage of research: The antibody has been used to characterize CD6 expression in the mouse and investigate the role of CD6 in T cell development and function. Applications: Research tool Phenotypic analysis Cell sorting Depletion of T cells and CD5 -positive B cells in mice Advantages: Well characterized In vivo administration results in sustained down regulation of CD6 off the surface of T cells Potential for development into a therapeutic antibody for autoimmunity or conditioning for hematopoietic cell transplantation