Microfluidic Bubble Bioreactor

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Integrated Microfluidic Bubble Bioreactor for Cell Capture Brief Description: This invention describes a methodology to improve the sensitivity of porous silicon optical sensors that will enable point of care use in detection of chemobiologics. Applications: This sensor can be designed to detect targets important in bioterrorism, environmental waste management, drug discovery, narcotic substance abuse, protein detection in biological samples (e.g. blood, urine, and saliva), and detection of gaseous targets can also be made possible. Advantages: The increasing need for rapid and portable biosensor technology is evidenced by the growing worldwide markets for environmental field testing (FT) and point-of-care (POC) biomedical diagnostic markets, the latter with obvious applications in home health testing (e.g. cholesterol, pregnancy, etc.), drug screening (e.g. sports, clinics, sobriety check points, etc.), and pathogen surveillance for military, homeland security and public health testing. A successful FT/POC platform technology will, in addition to speed, sensitivity and accuracy, be inexpensive and not require extensive training or sophisticated instrumentation for readout. There are many advantages of porous silicon technology for FT/POC sensing applications including inexpensive fabrication, precise control of pore morphology, intrinsic filtering properties, high surface area, versatile surface chemistry, capacity for label-free colorimetric readout, and compatibility with high throughput array and microfluidic technologies. This technology maps out the creation of such a device and explains the proper way in which to use it. Patent Information: Title Country Patent No. Issued Date Hybrid Target Analyte Responsive Polymer Sensor with Optical Amplification United States 8,841,137 9/23/2014