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Compared to alternative technology, this invention is chemically versatile, and cost-effective. It is more selective way to control hydro gel degradation.
About
Technology Description: The invention provides a means to selectively control the degradation rates of hydrogels and bioconjugates, such as for drug release in the pharmaceutical industry or implants in the biomaterials industry. Addition of thiols and maleimides is widely used in preparing biological conjugates and is known to lead to some product instabilities in vivo, allowing the reverse reaction (retro Michael addition) to occur. By using a specific thiol in the process, the retro Michael addition can be rendered permanent at physiological pH and temperature, introducing a novel technique for controlled degradation and release. Benefits: Compared to alternative technology, this invention is chemically versatile, and cost-effective More selective way to control hydrogel degradation Patent Status: The technology is patent pending with fully preserved U.S. patent rights available for licensing opportunities. U.S. Issued Patent (No. 9,044,515)