Knockout Mouse

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Summary: Researchers at UCLA have developed a mouse strain genetically modified to interrupt (knock out) the gene for glycerol-3-phosphate acyltransferase 4 (GPAT4; originally known as AGPAT6). This mutant mouse model is a valuable tool for investigation of the physiological function of GPAT4 in lipid metabolism, obesity, diabetes and related disorders. Innovation: Researchers at UCLA have developed a mouse strain genetically modified to interrupt (knock out) the gene for glycerol-3-phosphate acyltransferase 4 (GPAT4; originally known as AGPAT6). This mutant mouse model is a valuable tool for investigation of the physiological function of GPAT4 in lipid metabolism, obesity, diabetes and related disorders. Related Materials: Beigneux AP, Vergnes L, Qiao X, Quatela S, Davis R, Watkins SM, Coleman RA, Walzem RL, Philips M, Reue K, Young SG. (2006) Agpat6--a novel lipid biosynthetic gene required for triacylglycerol production in mammary epithelium. J Lipid Res. 47(4):734-744. [more] Vergnes L, Beigneux AP, Davis R, Watkins SM, Young SG, Reue K. (2006) Agpat6 deficiency causes subdermal lipodystrophy and resistance to obesity. J Lipid Res.;47(4):745-754. [more] Nagle CA, Vergnes L, Dejong H, Wang S, Lewin TM, Reue K, Coleman RA. (2008) Identification of a novel sn-glycerol-3-phosphate acyltransferase isoform, GPAT4, as the enzyme deficient in Agpat6-/- mice. J Lipid Res. 49(4):823-831. - See more at: https://techtransfer.universityofcalifornia.edu/NCD/20361.html#sthash.dp31o4st.dpuf