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The present invention provides a method for inhibiting osteoclast development and a method for preventing bone erosion by delivering an effective amount of a haloanilide.
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Summary This utility patent application claims the benefit of priority to co-pending U.S. Provisional Patent Application Ser. No. 61/635,525 filed Apr. 19, 2012. The entire contents of U.S. Provisional Patent Application Ser. No. 61/635,525 are incorporated by reference in its entirety into this utility patent application. The composition N-(3,4-dichlorophenyl)propanamide ("DCPA") is commercially available under the tradename "Propanil" for use as a herbicide. Its primary use in to control grassy weeds in rice fields because rice, as well as wheat, has naturally higher levels of acylamidase. Acylamidase enzymatically breaks DCPA into dichloroaniline (DCA) and water, thus inactivating the herbicide qualities of the DCPA. DCA is not toxic to plants, and the rice is unharmed but grassy weeds, which have low natural levels of acylamidase, are killed by the herbicide DCPA. Generally, the herbicide DCPA is applied numerous times during a growing season, often by spray plane because the rice is grown under very wet conditions.