The invention provides for compositions of deglycosylated HIV-1 glycoproteins and for their administration to mammals for antibody production.

About

Summary This invention describes a method for producing partially deglycosylated HIV-1 envelope glycoproteins through site-directed mutagenesis. Removal of multiple carbohydrate residues by mutation of their consensus N-linkage sites exposes gp160/gp120 protein domains to the host immune system and may lead to enhanced immune response. Such mutated derivations of gp160/gp120 retain normal structure and function, as measured by infectivity of virions bearing the mutated proteins. Applications The invention provides for compositions of deglycosylated HIV-1 glycoproteins and for their administration to mammals for antibody production.

Register for free for full unlimited access to all innovation profiles on LEO

  • Discover articles from some of the world’s brightest minds, or share your thoughts and add one yourself
  • Connect with like-minded individuals and forge valuable relationships and collaboration partners
  • Innovate together, promote your expertise, or showcase your innovations