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The present invention provides a method of enhancing a stem cell infusion comprising providing stem cells obtained from bone marrow, peripheral blood.
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Summary The present invention provides a method for enhancing umbilical cord blood engraftment comprising providing an amount of an umbilical cord blood, adding to the umbilical cord blood an effective amount of at least one of a granulocyte colony stimulating factor and a granulocyte macrophage colony stimulating factor, and optionally adding to the umbilical cord blood an effective amount of romiplostim, and optionally adding to the umbilical cord blood an effective amount of an erythropoiesis-stimulating agent, for forming a treated umbilical cord blood mixture for enhancing the engraftment of CD44 cells within said treated umbilical cord blood mixture. Preferably, the method of the present invention for enhancing umbilical cord blood engraftment, as described herein, includes wherein (i) at least one of the granulocyte colony stimulating factor and the granulocyte macrophage colony stimulating factor, (ii) the romiplostim, and (iii) the erythropoiesis-stimulating agent, are added to the umbilical cord blood in any order of addition for forming a treated umbilical cord mixture of the umbilical cord blood, at least one of the granulocyte colony stimulating factor and the granulocyte macrophage colony stimulating factor, the romiplostim, and the erythropoiesis-stimulating agent. Another more preferred embodiment of the method of the present invention for enhancing umbilical cord blood engraftment, as described herein, includes wherein (i) at least one of the granulocyte colony stimulating factor and the granulocyte macrophage colony stimulating factor, (ii) the romiplostim, and (iii) the erythropoiesis-stimulating agent, are added to the umbilical cord blood simultaneously for forming a treated umbilical cord mixture of the umbilical cord blood, at least one of the granulocyte colony stimulating factor and the granulocyte macrophage colony stimulating factor, the romiplostim, and the erythropoiesis-stimulating agent. In the methods of this invention, it is preferable that the erythropoiesis-stimulating agent is epoetin alfa. Another embodiment of these methods for enhancing umbilical cord blood engraftment include transplanting or transfusing the treated umbilical cord blood mixture to a patient.