Chemotherapy Drug Delivery

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Chemotherapy Drug Delivery Using Encoded Nanoparticles This invention offers a system and method for delivering high amounts of certain anticancer drugs to target cancer cells using modified nanoparticles. This effectively enhances the therapeutic window of the anticancer drugs, while opening pathways for multimodal performance and tailorability. Technology Overview Advances in nanotechnology have led to the use of nanomaterials in various medical applications. Nanoparticles, such as gold nanoparticles, offer a number of properties making their use in this emerging field of nanomedicine of particular importance. Most notably, gold nanoparticles can accommodate a wide range of surface chemistries which allows for various drug or biomaterial modifications, and they can be internalized by human cells with only minimally cytotoxic effects. Currently, most clinical anticancer drugs have relatively narrow therapeutic windows and limited purposes, indicating inefficient delivery and distribution of the drugs between diseased tissues and normal tissues. This invention offers a system and method for efficiently delivering high amounts of certain anticancer drugs to cancer cells through the use encoded gold nanoparticles. Drug loading at the nanoparticle involves the use of DNA, and each nanoparticle has a tailored drug loading ranging from 100-500. By adding additional chemistries at the surface, the particle becomes multimodal, which can include addition of targeting vectors, or imaging agents. When the nanoparticle is delivered to the target cancer cell, it carries a much higher payload than conventional drugs. This leads to increased toxicity and fewer side effects. By attaching the drug to the particle via an encoded, and non-covalent method, this approach is novel since previously FDA approved drugs do not change structure of chemistry. Moreover the system is scalable, and since the drug is concentrated many fold on each particle, also cost effective Advantages Drug loading is non-covalent, and does not change drug structure Drug loading is tailorable, and multiple different drugs can reside per nanpoparticle Nanoparticle can posses varied degrees of function and properties (e.g. multimodal) Limitations no limitations available. Other Information Inventors: Mathew Maye, http://chemistry.syr.edu/faculty/maye.html; James Dabrowiak; Colleen Alexander Suggested Uses Drug delivery (e.g. therapeutics, cancer, virus, and biofilm) Nanomedicines (e.g. multiple functions, new performance) Bioimaging (e.g. targeted delivery, imaging) Development Stage academic research Technology Sectors Biotechnology Health and Safety Nanotechnology Diagnostic Imaging Therapeutic Biomedical Drug Delivery Drug Screening Gene Therapy Medical Tags no applicable tags specified File Number 100649 IP Protection no associated IP specified Publications no available publications specified