Cerebrospinal Fluid

About

Invention Summary Analysis of cerebral spinal fluid is often used in the diagnosis of central nervous system (CNS) diseases and determination of CNS drug distribution post systemic administration. Rodent models of CNS disease progression and treatment have been routinely used during the preclinical phase of drug discovery/development. Currently, collecting cerebral spinal fluid requires immobilization of rodents on the flat surface of a stereotaxic platform which is very expensive and not easy to use with gas anesthetic tubing. Rutgers researchers have invented a wedge-shaped device that allows for the collection of cerebral spinal fluid from rodents easily. The design of the device has been optimized to allow for cerebral spinal fluid sampling without having to make a skin incision, a necessary procedure when using standard stereotaxic platforms. In addition, this wedge-shaped platform is easy to use with gas anesthetic tubing. Based on this design, a 3D printed device has been made and successfully tested for collecting cerebral spinal fluid from rats without skin incision or blood contamination, proving it well-suited for use in studies of CNS diseases and preclinical drug discovery applications. Market Application •  Routine sampling of cerebral spinal fluid for studies of CNS diseases •  PK/PD assessment in drug discovery applications •  Neurosurgical positioning Advantages •  Easy to use •  No need of skin incision •  No blood contamination •  Low cost •  3D printing plan ready for download