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The system is precise and inexpensive system, highly sensitive and accurate and increases Raman effect up to several orders of magnitude
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Summary Stanford researchers at the Gambhir Lab have developed a precise and inexpensive system to image cancers and identify tumor boundaries using surface enhanced Raman scattering (SERS) nanoparticles as tumor targeting contrast agents. This invention is embodied in a small flexible fiber optic based Raman device (diameter = 5.5 mm). This device has been carefully designed to be sent through the accessory channel of a clinical endoscope to sensitively detect these tumor targeted SERS nanoparticles while overcoming the limited depth of penetration associated with most optical techniques. Physicians will now have the ability to utilize the unique functional information Raman spectroscopy has to offer during endoscopic, laparoscopic or surgical procedures. This invention is an extension to Stanford docket S09-264 “Raman Endoscopic Probe for Ultrasensitive Detection of Disease in Conjunction with Surface-Enhanced Raman Nanoparticles” which describes a combined Raman endoscopic optical device with disease targeted SERS nanoparticles which can multiplex multiple targets in a clinical setting.