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This smart bioscaffold turned new cell-sensing platform can quantitatively fingerprint and differentiate the subtypes and changes of different cells.
About
This smart bioscaffold turned new cell-sensing platform can quantitatively fingerprint and differentiate the subtypes and changes of different cells (e.g. normal, cancerous, and stem) in the same or similar shapes under different chemical and/or physical stresses, without the need to destroy the cells.
Key Benefits
In this work, the electrochemically sensory nanofibers of titanate (a low-cost bioceramics) were grown first on top of a titanium metal, via a simple autoclave treatment, as shown in the previous disclosure of 7-12. These formed bioscaffolds were characterized by means of X-ray diffraction (XRD), scanning electron microscope (SEM), a couple with the energy dispersive X-ray analysis (SEM-EDX), etc. The bioscaffolds were then incubated with the indolent and deadly human breast cancer cells, and the normal breast cells, in both separate and mixed cases. The different cells have shown reproducible and significant differences in impedance change within certain frequencies on the sensory bioscaffolds. On this basis, different ratios of the cancer cells in the normal cells shifted the mixture's electrochemical signals quantitatively and reproducibly. This new finding has suggested that the cancer cells have altered the bioscaffolds surface charge-density much more than the normal cells while binding to the surface of nanofibers of the bioscaffold.
Applications
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