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This invention enables the detection of health problems such as Alzheimer’s disease, leucocyte loss, liver damage, cancer and AIDS with high specificity and sensitivity.
About
INVENTION Cellular thiols are essential biomolecules that play important roles in biological systems. Many health problems, such as Alzheimer’s disease, leucocyte loss, liver damage, psoriasis, cancer and AIDS are known to be associated with levels of cellular thiols. This invention reports for the first time of thiolspecific biomolecular probing on solid-state mediate. The novel probe is soluble luminogen which comprise an aggregation-induced emission (AIE) luminophore. Relying on the thiolene “click” mechanism and the AIE effect, a thiol-specific bioprobe in the solid state is resulted. The probe emits when it is exposed to L-cysteine, an amino acid containing a thiol group, but remains nonemissive when exposed to other amino acids that lack free thiol units. Similarly, the emission of TPE-MI was turned on only by the proteins containing free thiol units, such as glutathione. MARKET OPPORTUNITY Companies which focus on developing bio-fluorescent probes are welcome to exploit the performance of the probes. Key Benefits Allows detection with high specificity and sensitivity Emission can be easily detected by naked eye