Biohybrid Scaffold

About

Summary: A novel biohybrid scaffold is generated here by concurrent extracellular matrix (ECM) gel electrospraying and biodegradable elastomer electrospinning. ECM gel possesses good bioactivity and biocompatibility, but its weak mechanic properties and fast degradation limited its applications in clinic. Biodegradable elastomer could be processed into the sub-micro fibrous scaffold using electrospinning. This electrospun scaffold had attractive mechanical behaviors and good cytocompatibility, however, the poor cellular penetration and tissue integration due to its dense structure would delay the tissue formation and healing.  The novel developed biohybrid elastic scaffold fabricated by concurrent electrospray/electrospinning consists of interpenetrated ECM gel and elastomer fibers, where ECM gel would make the electrospun scaffold looser and provide the bioactivity and biocompatibility to accelerate cellular and tissue integration and growth, while elastomeric fibers would supply the sufficient mechanical properties and elongate the mechanical support.