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Controlled delivery of a therapeutic agent to the buccal, rectal and vaginal cavities.
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Overview The present invention includes a hot-melt ectruded film and method of preparation thereof. The film is made from a precursor composition containing at least a water soluble or water swellable thermoplastic polymer, preferably HPC and/or PEO, and a bioadhesive polymer. The film can also contain a therapeutic agent, preservative, buffering agent, antioxidant, super-disintegrant or absorbent, flavorant, colorant, water insoluble polymer, organic acid, surfacant, film modifier, and/or cross-linking agent. The film does not aontain a conventional plasticizer or a material which is generally recognized in the art as a plasticizer for extruded films. the film can be sized and shaped to provide a controlled delivery of a therapeutic agent to the buccal, rectal, urinal, vaginal, abdominal, cranial, opthalmic, nasal, sinus, or otic cavities. The film can also be used for the treatment of wounds.