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Many applications of the present technology can be envisioned, including, but not limited to, in personal hygiene, in bandages and wound healing, as a hospital disinfectant.
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Summary The present technology, developed by Dr. Shai Rahimipour of the Department of Chemistry, allows for easy sonochemical synthesis of PDA nanocapsules by a short, one-step process that employs only non-toxic components and reagents. The method is low cost and scalable. The resulting nanocapsules can be transported in a cost-efficient manner as a lyophilized powder and can be further functionalized. The additional functionalities, such as anti-bacterial and anti-fungal moieties, are expected to display high efficiency because of the relatively small capsule size achieved by this process and as a result of their clustering and orientation on the nanoparticle surface. Following functionalization,ready-to-use PDA nanoparticles can be developed for one-step application, together with attached functional moieties, as a “paint”, aerosol spray or gel. These application modalities would allow easy coverage of large surfaces and repeated on-site treatments, unlike with dip coating. The sonochemically-derived functionalized PDA nanocapsules have been demonstrated to display dose-dependent anti-bacterial and anti-biofilm activity, to be stable and non-toxic to mammalian cells.