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Ability to conduct the acyl substitution of carboxylic acids directly without product-isolation complications common to conventional dehydration methods.
About
The technology allows for ready access to a diverse assortment of amides through the direct functionalization of carboxylic acids and azides by using a chlorophosphite as a dual activating agent, and results in simplified product isolation due to the aqueous solubility of the byproducts generated. The bimodal reactivity of phosphite to unmask the latent electrophilicity of carboxylic acids and is directly applicable to the assembly of biologically active natural products and synthetic targets containing amides, lactams, and peptide linkages.
Key Benefits
Ability to conduct the acyl substitution of carboxylic acids directly without product-isolation complications common to conventional dehydration methods.