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Using a reporter cell line, causing the cells to send out a detectable signal when certain events happen internally. Whenever HCV is replicating, the cell will be easier to detect.
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Summary More than 170 million people worldwide are infected with the Hepatitis C Virus (HCV), which can lead to acute and chronic liver diseases. Since the virus will not reproduce in test tubes for more than a few hours it is very difficult to perform experimental research on it. This novel assay uses a reporter cell line, causing the cells to send out a detectable signal when certain events happen internally. Whenever HCV is replicating, the cell will emit green fluorescence. The fluorescence is then tracked in the cell culture through flow cytometry. Applications: HCV testing Rapidly identify and isolate antiviral drug candidates Advantages: Easy to use Identifies HCV quickly relative to other assays