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A database of human genetic information. The database encompasses clinical information including dosing guidelines and drug labels and potentially clinically actionable gene-drugs
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Stanford University researchers have developed a database of human genetic information. The database encompasses clinical information including dosing guidelines and drug labels, potentially clinically actionable gene-drug associations and genotype-phenotype relationships. PharmGKB collects, curates and disseminates knowledge about the impact of human genetic variation on drug responses. Further information can be found on the PharmGKB website. Publications: Ashley EA, et al. Clinical assessment incorporating a personal genome. Lancet. 2010 May 1;375(9725):1525-35. Ormond KE, Wheeler MT, Hudgins L, Klein TE, Butte AJ, Altman RB, Ashley EA, Greely HT. Challenges in the clinical application of whole-genome sequencing. Lancet. 2010 May 15;375(9727)1749-51. Hansen NT, Brunak S, Altman RB. Generating genome-scale candidate gene lists for pharmacogenomics. Clin Pharmacol Ther. 2009 Aug;86(2):183-9. Thorn CF, Klein TE, Altman RB. Pharmacogenomics and bioinformatics: PharmGKB. Pharmacogenomics. 2010 Apr;11(4):501-5.