Register for free to
view the full innovation profile.
The present invention describes an approach to identify antigenic mimics of conformational epitopes recognized by broadly neutralizing antibodies.
About
Brief Description: The present invention describes an approach to identify antigenic mimics of conformational epitopes recognized by broadly neutralizing antibodies, including antibodies known to neutralize HIV-1. Applications: The surface HIV -1 envelope glycoprotein subunit, gp 120, is a major target for virus-neutralizing antibodies, but immunization with recombinant gp 120 failed to elicit broadly neutralizing antibodies and has failed to demonstrate protective efficacy in a Phase III clinical trials. Advantages: The present invention relates to polypeptides derived from the tenth fibronectin type III domain from human fibronectin ("FNfn 1 0"), fibronectin type III to generate antibodies (i) binding to a neutralizing monoclonal antibody reactive to HIV-1 or inducing a neutralizing immune response against HIV-1.